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KMID : 1144820230290030103
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대한의생명과학회지
2023 Volume.29 No. 3 p.103 ~ p.108
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Action Mechanism of Enhancers for Activating Gene Transcription
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Kim Yea-Woon
Kim Ae-Ri
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Abstract
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Enhancers are cis-elements to regulate transcription of cell/tissue-specific genes in multicellular organisms. These elements locate in upstream or downstream regions of target genes and are found in a long distance up to 100 Kb in some cases. Transcription factors and coactivators bind to enhancers in a chromatin environment. Enhancers appear to facilitate the transcription of target genes by communicating with promoters and activating them. As transcription activation mechanism of enhancers, chromatin looping between enhancers and promoters, tracking of enhancer activity to promoters along the intervening regions, and movement of enhancers and promoters into transcription condensates have been suggested based on various molecular and cellular biology studies. These mechanisms are likely to act together rather than exclusive each other for gene transcription. Understanding of enhancer action mechanism may provide a way to regulate the transcription of cell/tissue-specific genes relating with aging or various diseases.
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KEYWORD
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Enhancer, Promoter, Looping, Tracking, Transcription condensate
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